I think most American indie rockers prefered the usual street drugs: pot, coke, heroin. And when they get a little money, that doesn't really change their habits. Kim Deal: former pothead, boozer, chainsmoker (now clean & chubby.) Kelly deal: made it all the way up the ladder to heroin & rehab. Steve Malkmus: big pothead til he started a family (I heard Spiral Stairs prefers the coke.) Replacements: famous boozehounds, but cocaine was their real favorite. Husker Du: could have taken a page from that Japanese group and called themselves "Speed Weed & Norton"! etc.
Prescription drugs are more for the "Hollywood" set: Michael Jackson, Courtney Love. (And perhaps country stars too, in the old tradition of pillhead Johnny Cash.)
And I don't see anything "shoe-gazery" about Breeders or Pixies. Have you heard "Last Splash"? That's pop-rock with surf beats! And better than any Nirvana album.
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