Another Reaper user here - absolutely love it. Never noticed any distortion problems, occasional glitches when running too many plugins but adjusting buffer size and/or freezing tracks sorts it. PC upgrade I'm hoping will help too (not transferred all the preferences over yet so haven't had chance to try it out). I think it was the beta of Asio4all that allowed 2 soundcards to be used at once which is great - can process 4 channels of guitar through the Black Box amp modeller and whatever hardware through my main soundcard without having to fiddle about reconnecting speakers or headphones or other settings.
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